Signs point to global influenza oubreak--WHO warning

GENEVA (Reuters) - Indonesia's first human bird flu case, coupled with more birds dying elsewhere including Russia, are signs a long-dreaded global influenza pandemic may be approaching, the World Health Organisation (WHO) said on Friday.

Health officials fear the virus will mutate and mix with human influenza, creating a deadly pandemic strain that becomes easily transmissible and could kill millions of people.

Margaret Chan, WHO's new director for pandemic influenza preparedness, said there had been no known sustained human to human transmission of the deadly virus, but called for stepping up disease surveillance among poultry and humans worldwide.

Indonesia this week confirmed its first death from the virus, which has so far killed more than 50 people since late 2003 in Vietnam, Thailand and Cambodia, roughly half of the known cases.

An Indonesian government official was confirmed as having died of the H5N1 bird flu virus, but results of laboratory tests on his two young daughters who also died are still awaited.

"This is more evidence for us to be concerned about developments in the region," Chan told a news briefing.

"This is perhaps the only time since 1968, which was the last pandemic, that we are getting signs, symptoms and warnings from nature ... More and more birds are dying in different parts of the world -- this is the kind of signals, and early warnings that we are referring to."